phenytoin will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lessen in fentanyl plasma concentrations, not enough efficacy or, probably, improvement of a withdrawal syndrome inside of a patient who has made Actual physical dependence to fentanyl.

iloprost, fentanyl. Possibly will increase effects from the other by pharmacodynamic synergism. Modify Therapy/Watch Closely. When administering iloprost IV, consider non permanent discontinuation of concomitant vasodilators or other medications that lower blood pressure to mitigate potential additive hypotensive effects.

drospirenone will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.

Cases of serotonin syndrome, a potentially life-threatening ailment, reported with concomitant utilization of serotonergic drugs; this may manifest within the encouraged dosage selection; the onset of symptoms generally take place within a number of hours to a couple of days of concomitant use, but may well take place later than that; discontinue therapy straight away if serotonin syndrome is suspected

Watch Intently (1)somapacitan will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Monitor Carefully (1)glycerol phenylbutyrate will decrease the level or effect of fentanyl fentanyl co to by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Avoid use when taking any oral drug that's depending on threshold concentrations for efficacy. Interactions listed are consultant examples and don't incorporate all achievable clinical examples.

fentanyl will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

Your medical professional may perhaps swap you to definitely morphine tablets, liquid or another similar painkiller so they can reduce the dose much more gradually.

إعطاء عبر الأدمة، حقن عضلي، حقن وريدي، عبر الفم، إعطاء تحت اللسان، إعطاء شدقي، إعطاء أنفي

If coadministration of CYP3A4 inhibitors with fentanyl is essential, keep an eye on patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose changes right until stable drug effects are accomplished.

Check Closely (1)nirmatrelvir/ritonavir will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

turmeric will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

Drugs which have quantity boundaries affiliated with Just about every prescription. This restriction generally boundaries the quantity on the drug that may be covered.